Season 3

EP. 040

Andrew Yang is an entrepreneur, former 2020 Democratic presidential candidate, and author of "Forward: Notes on the Future of Our Democracy." A lawyer-turned-entrepreneur, Yang explains how he transformed early startup failures into success and why he's now intent on bridging partisan divides in America.  In 2021, Yang became an Independent and launched the Forward Party, which seeks to counter the political polarization in America. He and Joe discuss what policy reforms are needed to change incentives and repair America's political and cultural fabric.

EP. 041

I've known Iyinoluwa "E" Aboyeji since he was an aspiring, 19-year-old entrepreneur.  Today, he's the founder of two African unicorns, Andela and Flutterwave — the latter of which is now the continent's most highly valued tech startup at over $3 billion. We discuss the challenges he overcame, plus those that remain, and why he's bullish on Africa's future.  As the general partner and co-founder of Future Africa, "E" now invests in over a hundred African startups. He shares strong opinions on the cultural differences between Nigeria and the U.S. -- and the unique positive aspects we can learn from each society.

EP. 042

Kimmy Scotti is Founding Partner of 8VC and the Co-Founder & Chairman at Fig.1. After launching a popular consumer brand as a teenager, Scotti went on to tackle the convoluted and broken PBM industry and built a powerful cost-saving alternative for millions of consumers. She explains her philosophy for building in complex sectors and how she applies that at 8VC through mentoring founders, identifying talent, and generating alpha.  She also takes us behind the scenes of building Fig.1 and using cutting-edge science to create a superior skin care product.

ryan holiday
EP. 043

Ryan Holiday is a college dropout turned best-selling author and publisher of the world's largest podcast and newsletter focused on Stoic philosophy: the Daily Stoic.  Holiday began his career exposing the media manipulation playbook and then used those same tactics for good, educating millions on applying ancient wisdom to modern life. In this episode, he explains Stoicism's impact on America's Founding (did you know the most popular play in 18th-century America focused on a Stoic philosopher?) and why many of our challenges today stem from society's ignorance of Western Civilization's core principles and virtues. He also offers poignant personal advice that will transform how you think about bedtime with your kids and other daily routines.

clay johnston
EP. 044

Clay Johnston is the Former Dean of the University of Texas Dell Medical School and Co-founder and Chief Medical Officer of Harbor Health. Johnston received his MD from Harvard and Ph.D. from UC-Berkeley before leading a distinguished career as an academic neurologist. He then spearheaded the launch of UT's Dell Medical School, pioneering a more innovative curriculum and cutting costs within the system - sometimes as high as 80%, while improving patient results!  Learn how he's scaling these lessons into our broader health system with Harbor Health - a new startup designed to transform healthcare as we know it and dramatically reduce costs while improving patient outcomes.

EP. 045

John Mack is the former CEO and Chairman of the Board of Morgan Stanley and author of the new book, “Up Close and All In: Life Lessons from a Wall Street Warrior.” Mack details his unlikely journey from small-town North Carolina to the heights of Wall Street and the leadership lessons that got him there. He explains why personal character and respect are paramount, powerfully illustrated by the unlikely relationships he forged that ended up saving the firm during the 2008 financial crisis. Mack is not only a Wall Street legend, but he and his wife Christy led Morgan Stanley to build New York City's first children's hospital and contribute to many other philanthropic causes.

sec. mike pompeo
EP. 046

Sec. Mike Pompeo is a former entrepreneur, congressman, CIA Director, Secretary of State, and author of the new book, "Never Give an Inch: Fighting for the America I Love." From his early days running an aerospace company to negotiating with the world's most notorious authoritarian leaders, Pompeo discusses his leadership philosophy and how to project strength in critical moments. He details his efforts to reform Langley and Foggy Bottom, and warns against dysfunctional ideology seeping into our military and intelligence agencies. He also reveals how the Abraham Accords came to fruition, why the Trump Administration failed to ban TikTok, and how close the U.S. came to a deal with North Korea that may have changed the course of history.

EP. 047

John Chambers is the former Chairman and CEO of Cisco, responsible for growing the company from nearly $2 billion in revenue to almost $50 billion during his tenure. John is a legend in Silicon Valley, and a close advisor to leaders around the world including many CEOs and heads of state. Pankaj Patel was Cisco's former Chief Development Officer and led a $38 billion portfolio with over 26,000 engineers. Together, they made Cisco a global leader.   Now, they're reinventing enterprise networking with Nile, a new startup that will bring networking into the cloud and apply AI to improve the customer experience and cut tens of billions of annual cost and hassle. Learn lessons from how Chambers and Patel took Cisco to the top, and how they're transforming networking again.

EP. 048

Rahul Gandhi is the CEO and President of Clutter (formerly MakeSpace) – a leader in the self-storage industry. The son of Indian immigrant entrepreneurs, Rahul cut his teeth serving customers at his father’s Arby’s franchise. He saw his family succeed — and almost lose everything — in the highly-competitive restaurant business. He talks candidly about overcoming the fear of failure and making the leap from venture capital to launching MakeSpace. He learned every inch of the business, from driving the trucks to packing boxes, in order to build a software solution that could disrupt the $38 billion industry and dramatically improve the moving and storage experience for consumers.

eboo patel
EP. 049

Eboo Patel is the Founder and President of Interfaith America and author of "We Need to Build: Field Notes for Diverse Democracy."  Why did a Rhodes Scholar like Patel — and so many in academia — become social activists preoccupied with race and oppression? And how did a college professor jolt him out of this dogmatic ideology toward embracing pluralism and social entrepreneurship? Learn from Patel's journey and efforts to steer more Americans away from zero-sum thinking toward building better alternatives. He uses powerful vignettes from history, like the Ottoman Empire welcoming Jewish refugees in the 15th century, to remind us that our shared heritage can — and should — transcend identity politics.

troy carter
EP. 050

Troy Carter is an iconic music manager who helped launch Lady Gaga to stardom and worked with many prominent artists like Eve, John Legend, and Meghan Trainor.  Carter's work ethic and obsession with hip-hop helped him rise from a tough upbringing in Philadelphia, where his mother often had to choose between paying the water or electric bill each month. He ran errands for Jazzy Jeff and the Fresh Prince (Will Smith) before interning for P. Diddy and eventually launching his own management company. He fought through adversity at each stage of his career; he reveals how long it took before a single radio station would even play one of Lady Gaga's songs.

He's currently supporting independent artists through his new company Venice Music and his passion for representing the "little guy" also extends to one of the most important policy issues of our time: school choice. Wait until you hear his courageous views on teachers unions and why he's not afraid to stand up for opportunity and accountability in spite of potential backlash.

ADm. bill mcraven
EP. 051

Admiral Bill McRaven is an American hero and former Commander of U.S. Special Forces Command who oversaw the planning and execution of the raid to kill Osama bin Laden. He's a retired Navy SEAL and four-star admiral whose command experience and academic writings helped shape U.S. Special Forces into the finest fighting force in the world. He's also a best-selling author and former Chancellor of the University of Texas System. In this episode, Adm. McRaven shares leadership lessons from his distinguished career, explains how the Bin Laden raid almost went awry, and reflects on why his "Make your bed" commencement address went viral to hundreds of millions of people worldwide. He also weighs in on current events like modernizing the Defense Department, Russia's surprising failures in Ukraine, and how the U.S. should address the rise of China.

yitz applbaum
EP. 052

Yitz Applbaum is a philanthropist, international bon vivant, and accomplished venture capitalist specializing in Israel and the Middle East. He began his career building a banking software company (acquired by Bank of America) before joining Lightspeed Ventures and later founding MizMaa Ventures.  In this episode, he discusses how Israel transformed from a nation of impoverished refugees into an innovation powerhouse. Looking ahead, he explains how the Abraham Accords are reshaping the Middle East economically and culturally  — Yitz, an orthodox Jew, is currently Chairman of a genome sequencing company in Saudi Arabia!

He also expounds on some of the most important recent archeological discoveries in Israel, given his role on the Board of the Western Wall Heritage Foundation.  Moreover, Yitz is a prolific collector of whiskey and Kosher wine — we open our favorite bottle of scotch in this episode!

joe gebbia
EP. 053

Joe Gebbia is the co-founder of Airbnb, which grew from an experiment in his San Francisco living room into a multi-billion dollar global company that transformed the hospitality industry. And his new startup, Samara, is reimagining how homeowners utilize their backyards by offering state-of-the-art Accessory Dwelling Units.  In this episode, Gebbia explains the unlikely genesis of Airbnb, the challenges in unlocking the sharing economy, and how Samara could address many of America's housing issues.

We learn about Gebbia's most famous high school prank - and how he channels his creative, entrepreneurial energy into reshaping how people live, travel, and engage with the world around them.  We also discuss Gebbia's inspiring philanthropic work, which has touched millions of lives, and hear why he changed his perspective on nuclear energy and now believes it’s one of the most important technologies for the future of the planet.

peter attia
EP. 054

Peter Attia is a renowned physician, podcast host, and best-selling author of "Outlive: The Science & Art of Longevity." Peter received his M.D. from Stanford University and was awarded "Resident of the Year" in general surgery at Johns Hopkins University, but left medicine before coming back years later with new perspectives and becoming one of the world's most sought-after longevity experts. In this episode (we are also joined by our mutual friend and best-selling author Ryan Holiday), Peter explains the core principles and exercises to maximize and extend quality of life. We also discuss the obesity paradox and why Americans, on average, are becoming increasingly unhealthy -- and how we can reverse that troubling trend.

Peter is trusted by a lot of amazing people I know, and he continues to innovate and test his theories, diets, and exercises on himself. His wisdom and expertise have improved lives around the world, and will challenge you to rethink your daily habits.

nathan mintz
EP. 055

Nathan Mintz is the Founder and CEO of Spartan Radar and, previously, the Co-Founder and CEO of Epirus.  In his twenties, Nathan sought to reform California's broken government and ran for state assembly twice, albeit unsuccessfully. Yet, his loss became our gain as he's become a leading entrepreneur in directed energy and radar systems.  In fact, Nathan has built a reputation for attracting some of the best engineering talent in the country.

He began his career at Raytheon and Boeing, designing sensors and electronic warfare systems for the U.S. military.  He used that knowledge to launch Epirus, which now boasts the world's most powerful directed energy system (Leonidas).  He's currently building Spartan Radar and developing software that can dramatically improve automotive radar and accelerate the path to ubiquitous self-driving vehicles.  We discuss his entrepreneurial journey and knack for attracting top talent, as well as the economic and cultural implications of widespread autonomy.  He also explains why he's bullish on a new space age and predicts SpaceX will reach Mars in the next several years!

maria davidson
EP. 056

Maria Davidson is the Founder and CEO of Kojo. Each year, the U.S. construction industry spends roughly $250 billion on materials, much of which is still managed by pen and paper (Excel is considered cutting-edge). Kojo is a software solution that digitizes the process, à la Amazon for contractors, and vastly improves productivity, efficiency, and safety. Learn why it took an immigrant entrepreneur and industry outsider like Maria to help modernize a giant sector of our economy that is notoriously slow to change.

Maria was born in the Soviet Union, raised in Israel, and moved to London at 13. She graduated from Oxford University where she served as President of the Oxford Union. We discuss the most controversial speakers she invited and why encountering divergent viewpoints is fundamental to the health of a free society. After Oxford, she landed at Goldman Sachs in London before making the leap to Silicon Valley and joining the 8VC team. Applying her philosopher's perspective, Maria sought to understand why it's extremely difficult and expensive to build in America today. That led her, at only 26-years-old, to found Kojo, which is now processing over $1 billion in materials orders for thousands of customers nationwide.

balaji srinivasan
EP. 057

Is the U.S. on the verge of an unprecedented banking crisis? Other than Bitcoin, where is Balaji keeping his money? Could the government try to confiscate assets like FDR's gold seizures in the 1930s? Will red and blue states break into a cold civil war over the fiscal fallout?  Learn why Balaji is sounding the alarm and why these scenarios may not be as far-fetched as you might think. We also discuss the roots of the current banking crisis and debate whether America's dysfunctional and broken institutions can be saved, or if it's too late to rescue our republic.  

Balaji is one of the leading investors, entrepreneurs, and writers of our time. For years, he's been an outspoken advocate for cryptocurrency and the larger decentralized finance movement, while boldly warning of the consequences of our nation's reckless fiscal policy.  He was formerly the Chief Technology Officer of Coinbase and General Partner at Andreessen Horowitz.  He's also the author of "The Network State: How to Start a New Country" and host of the Network State Podcast.

eliot hodges
EP. 058

How do we ensure that capital flows more efficiently to the best ideas and creates more value for society? One way is to enable more people to access the best investment opportunities, many of which are in private markets (aka alternative investments) that are notoriously difficult to navigate. It can take a team of lawyers to manage the mountain of paperwork and outdated analog processes — a stark contrast to one-click retail investing in public markets. 

Eliot Hodges, the CEO of Anduin, and his team are solving this problem. Anduin's software platform is digitizing the private markets and democratizing access — they've already helped more than 25,000 investors onboard at nearly 500 funds and raise over $45 billion in capital.  An early employee at Palantir and Blend, Eliot explains his entrepreneurial journey and why Anduin's success is important for the innovation economy. What also makes Anduin unique is that it's a Silicon Valley startup employing top talent in Vietnam.  Eliot discusses how he encourages collaboration across different cultures and why the caliber of engineering skills outside the U.S. is reshaping the tech landscape. 

EP. 059

In India, "entrepreneur" was once a dirty word; today it's one of the most desirable career paths for young people. How did this transformation occur? How did the world's largest democracy break out of socialism? What does the remarkable rise of India augur for the 21st century?

We explore these questions and more with Aditya Berlia, a serial entrepreneur, investor, philanthropist, and the co-founder and pro-chancellor of the Apeejay Stya University (ASU). Adi discusses his pioneering efforts in India's education sector, including building ASU — the country's first industry-focused technology and liberal arts university. He also explains his work around the world in biotech and how the U.S. FDA can more effectively partner with international manufacturers looking to access U.S. markets.  Finally, he provides a unique perspective on America's challenges and how the world's two largest democracies can more closely ally and partner in the decades ahead.

dr. rebekah gee
EP. 060

Could modernizing one of medicine's oldest practices — the home visit — dramatically improve care for disadvantaged populations? What if doctors and nurses could treat an entire family in their home through a value-based care model that aligns incentives for both providers and payers? These are the questions Dr. Rebekah Gee aims to answer with Nest Health, a new health startup that's reinventing in-home care.

Dr. Gee is uniquely suited to lead this effort: she's a mother of five and OBGYN who led Louisiana State University's healthcare program from 2020 to 2022 and the state of Louisiana's Department of Health from 2016 to 2020. She made a name for herself by deftly managing a $14 billion budget and negotiating drug pricing to make a costly Hepatitis-C drug available for tens of thousands of Louisianans. Previously, Dr. Gee served as the Medicaid Medical Director for Louisiana Medicaid and also worked on the healthcare transition team for President-elect Barack Obama. She's now applying the learnings from her extensive public service to build Nest, which is focused on improving health outcomes for Louisiana families on Medicaid. Dr. Gee explains the hurdles she overcame to innovate within Medicaid and how Nest's in-home care model could scale throughout the country to transform lives, cut costs, and increase productivity in American healthcare.

guillermo rauch
EP. 061

How did a high school dropout from Argentina build a multi-billion dollar web infrastructure company that supports many of the world's largest companies and brands? This is the story of Guillermo Rauch, CEO of Vercel.

At an early age, Guillermo developed a passion for open-source projects and began building websites and products for clients around the world at only 13 years old. He dropped out of high school to program full-time and eventually made his way to the U.S. where he's now leading one of the world's fastest-growing internet infrastructure companies.  Walmart, Facebook, Mr. Beast, and many other industry leaders build and deploy products online using Vercel because of its superior reliability, functionality, and speed.  If you want to learn more, check out this helpful explainer.

In this episode, Guillermo details his entrepreneurial journey, the origins of Vercel, and how he cultivates top engineering talent.  We also dive into what precipitated Argentina's fall from global power, and why pessimism and political dysfunction may go hand-in-hand.

ben rubenstein
EP. 062

What are the three most important attributes of a successful salesperson? How do you identify talent capable of withstanding constant rejection? And how do you hire hundreds of salespeople while maintaining mission and culture?

Discover how Ben Rubenstein scaled two startups to big exits, and why he believes resumes are largely meaningless for sourcing top sales talent. His first company, Yodle, took on the Yellow Pages by bringing thousands of small businesses online and into the digital age. Ben started as a one-person sales team living with friends, sleeping on an air mattress, and moving every few months until he broke through, eventually building a thousand-person sales team. Next, he founded Opcity, a real estate lead referral service, and once again scaled it into a large salesforce until the company was acquired by

Ben is currently building Setpoint, a software platform that automates asset-based lending and capital markets operations, enabling real-estate, auto, consumer, and other asset-backed borrowers to offer next-generation credit options to consumers. In addition, Setpoint has launched a second debt fund to support Proptech startups. Learn about the most exciting innovations in real estate and why Ben believes AI will upend how we think about careers and areas of expertise.

eddie margain
EP. 063

Eddie Margain quickly ascended the ranks as a Mexican entrepreneur but fled the country when the cartels threatened his family.  How does a nation lose its rule of law and does he see similar trends in America? Why was he inspired to build Austin FC and what did it take to bring the first professional sports team to the capital of Texas?

We explore these topics and more with Eddie, co-founder of Austin FC and Managing Partner & Founder of Pixiu Investments (current investments include, among others, the historic Scarbrough Building and apparel maker Outdoor Voices). Eddie is a true leader and pillar of the community who serves as President of the Greater Austin Crime Commission and also supports myriad other philanthropic causes.

His entrepreneurial journey began in Mexico, first by founding an internet access provider and later building companies to manufacture and distribute mobile phones. In this episode, Eddie explains how his homeland surrendered to narcoterrorism, why he fell in love with Austin, and what motivated him to build the city's first soccer club.

dr. alex karp
EP. 064

Over the past two decades, Palantir has prevented a large number of terrorist attacks, deployed the most advanced civil liberties data infrastructure throughout Western countries, and changed the course of history. Today, its technology is most evident on the battlefield in Ukraine, where its software has provided the Ukrainians a devastating advantage over Russian forces.  And now, Palantir is quickly becoming the leading AI platform in the world for large organizations.

How did a small startup overcome overwhelming institutional resistance to become one of the most important software companies in the world?  And what can we learn from its CEO, Dr. Alex Karp — How does he attract the very best engineering talent?  How did his dyslexia and outsider upbringing impact his views on the world and how Palantir is designed?  We cover these questions and more in a special conversation between two of Palantir's co-founders.

Dr. Karp holds a B.A. from Haverford College, a J.D. from Stanford Law School, and a Ph.D. in philosophy from Goethe University in Frankfurt, Germany, where he studied under Jürgen Habermas and other leading intellectuals. In this episode, we explore the impact of philosophy on his life and why he ultimately left academia to build.  We share some of our favorite stories from Palantir's early days, discuss how to reform the Pentagon to improve its results, and look ahead to how AI is changing the nature of warfare.  Dr. Karp is one of the wisest leaders I know, and you'll learn how his iconoclastic views on software, patriotism, talent, and innovation have been proven right over the past years, and what they mean for the future.

marc andreessen
EP. 065

What's the best optimistic case for AI? Could AI actually save the world? What do the AI doomsayers get wrong? 

We dive deep into the AI debate with Marc Andreessen, cofounder and general partner at Andreessen Horowitz, for a special conversation held during the 2023 University of Austin Forbidden Courses. We explore Marc's recent essay and why he believes AI could improve productivity, reduce human drudgery, and allow us to spend more time creating art or music, investing in relationships, and doing things that make us more human.  Marc challenges the popular narratives on machine learning — why do we assume superintelligence will turn evil, for example? — and applies lessons from history to make a powerful case for embracing the AI age. 

However, his optimism is tempered by the realities of politics, and we debate whether it's the fault of the citizenry or special interests for stymieing innovation and progress.  We also discuss how philosophical frameworks, like the precautionary principle, have been used to inhibit progress, and why, sometimes, it takes great leaders creating exponentially better products or policies to overcome the status quo. Finally, we field a variety of smart and fun questions from students on AI, politics, and venture capital. 

bob mcgrew
EP. 066

Bob McGrew is at the epicenter of the AI revolution.  As the VP of Research at OpenAI, he's instrumental in breakthroughs that are reshaping the world, from building GPT models and launching ChatGPT to overseeing the Dall-E project.  How was GPT-4 trained and what will GPT-5 look like? Why does ChatGPT respond with certain biases and how do they correct for that? What breakthrough led Bob to believe AGI could be achievable?

Bob and I were in Phi Psi together at Stanford and both interned at PayPal in its early days.  We hired Bob as the second engineer at Palantir, where he built and shipped the first products for the intelligence community and went on to lead engineering and help run the company.  Bob joined OpenAI part-time in 2016 and full-time in 2017, where he's been at the forefront of AI innovation.  In this episode, we discuss the early days of Palantir, how he knew AI's moment had arrived, and the most important research projects underway at OpenAI.  We also look ahead to what GPT-8 could unlock for humanity and what's needed for Large Language Models to move beyond mimicking humans to higher forms of intelligence and creativity.

New Episodes Weekly

Season 2

EP. 018

Over the past few decades, the U.S. military’s long-held advantages have waned. Today, we are reliant on outdated technologies and in jeopardy of falling behind China. Bo Marr, the co-founder and Chief Technology Officer of Epirus, is bucking the trend. Marr and his team invented the world’s most powerful phased array, Leonidas, that can disable drones and other electronic systems from great distances. This modern force field fills a vital technological gap for the U.S. military as it prepares for 21st-century warfare and a new era of asymmetric threats. [Joe co-founded Epirus in 2018 with the Build Program of 8VC, the venture capital firm he founded and manages.]

Maleka Momand
EP. 019

Maleka Momand is the co-founder and CEO of Esper, a technology platform that transforms how governments oversee the regulatory process.  In recent decades, the size of the administrative state has exploded. Yet, many regulators still operate via Word, Excel, and, in some cases, pen and paper!  This has led to a lack of transparency and accountability, not to mention a morass of outdated, disjointed regulations.  By applying data analytics and artificial intelligence to augment regulators and regulatory processes, Esper is improving how governments function and interact with the business community. [Joe and his wife Tayler are proud co-founders of Esper.]

Ro khanna
EP. 022

Congressman Ro Khanna is the Democratic Congressman from California’s 17th District, which covers large swaths of Silicon Valley.  A self-described "progressive capitalist," Khanna bucks the current political norms and works to advance meaningful bipartisan legislation.  In this episode, we debate income inequality, wealth taxes, and other hot-button issues, but also find common ground on reasonable regulations for Big Tech, introducing more innovation into healthcare, and promoting nuclear energy.  His forthcoming book is titled “Dignity in a Digital Age” and focuses on closing the digital divide in rural America.

Chris sprowls
EP. 023

Chris Sprowls is the Speaker of the Florida House of Representatives.  Under his leadership, Florida has set itself apart as one of the most innovative state legislatures in the country, slashing regulations that prop up entrenched interests and injecting true competition into the marketplace.  We discuss his strategy for successfully combatting cronyism in healthcare, pioneering the biggest school choice expansion in the country, and other courageous reforms  -- many of which passed on a bipartisan basis.  Speaker Sprowls's success should embolden other like-minded reformers and leaders across our country.

Charles Koch
EP. 024

Charles Koch, Chairman and CEO of Koch Industries, is one of the great business minds of our time.  He grew a small engineering firm from $21 million in revenue to over 10,000 times the revenue.  Yet in both his business and philanthropic work, he is first and foremost a philosopher.  Koch explains how thinkers such as Abraham Maslow and Joseph Schumpeter shaped his outlook on the conditions for human flourishing, and why it's important to enable every employee to self-actualize.  Rejecting centralized top-down systems, Koch developed Market-Based Management -- a philosophy that enables his companies to constantly reinvent themselves through virtuous cycles of mutual benefit that provide value to both employees and customers.

Amb. Kelly Craft
EP. 025

Ambassador Kelly Craft is a businesswoman, philanthropist, and former diplomat who served as U.S. ambassador to the United Nations from 2019 to 2021 and U.S. ambassador to Canada from 2017 to 2019.  She played an integral role in shaping major foreign policy decisions and achievements, such as the landmark Abraham Accords and the USMCA trade agreement.  In this episode, she discusses some of the most pressing U.S. challenges abroad, including speaking up for human rights during the Beijing Olympics, developing a comprehensive strategy for China, responding to Russian military threats against Ukraine, and galvanizing U.S. allies to defend our shared values.

pano kanelos
EP. 026

Pano Kanelos is the President of the University of Austin (UATX), the most ambitious new university venture in America in decades. Recognizing the plight of America's higher education system, Pano stepped down as the President of St. John's College to build a new institution rooted in the pursuit of truth, open inquiry, and educating the next generation of American leaders. In this episode, Joe and Pano discuss the failures of modern academia and why it's time to take on the bold task of building a new world-class university. [Joe is a co-founder of UATX and Chairman of the Board of Trustees.]

tyler cowen
EP. 027

Tyler Cowen is a professor, best-selling author, blogger, podcaster, and one of the most influential economists of this generation.  In the early days of the pandemic, Cowen launched the Fast Grants program, which funded COVID-related science in less than 48 hours -- a remarkable feat in the medical sector.  He discusses his efforts to accelerate innovation, including his work to transform how investors identify and back the next generation of brilliant entrepreneurs. An all-around polymath, Cowen also reveals the technologies and breakthroughs that excite him most for the decades ahead.

Thomas Chatterton Williams
EP. 029

Thomas Chatterton Williams is a writer, cultural critic, fellow at the American Enterprise Institute, and author of two critically-acclaimed books on race in America. In this episode, he discusses the dangers of Critical Race Theory and how to move beyond race-first, collectivist mindsets.  He also discusses his forthcoming book, "Nothing Was the Same," which traces the recent rise of illiberalism and polarization in the U.S.  Even though we may find certain ideas or theories (like CRT) noxious, Williams argues for more engagement and debate, not banning or censoring materials, as the best path toward progress.

Jared Meyer
EP. 030

Jared Meyer is the Executive Director of Cicero Action. In this episode, Jared discusses how special interests stifle competition and why Cicero Action is using the special interests' playbook against them to promote innovative, bottom-up reforms.  He explains the government affairs strategy that creates real policy changes in states across the country, from expanding telehealth and improving parole and probation reforms, to realigning higher education incentives and fixing homelessness.  This conversation shows how transparency, accountability, and competition are possible when political leaders have the tools—and the courage—to stand up to cronyism and entrenched interests. [Joe is the founder and Chairman of Cicero's 501c3 and 501c4 organizations.]

Jeannette zu Fürstenberg
EP. 031

Dr. Jeannette zu Fürstenberg is Co-Founder and General Partner of “La Famiglia”, a Berlin-based Venture Capital fund, and holds a Ph.D. in Philosophy and Entrepreneurship from the Free University of Berlin.  She’s also a princess of one of Europe’s oldest royal families by marriage, as well as a thoughtful leader in the innovation and business world. In this episode, she traces the birth of entrepreneurship from the Renaissance and explains how breaking down the silos of guilds led to a creative explosion -- and how we can apply those lessons today. Dr. Fürstenberg specializes in connecting old and new world industries and discusses how to transform the 21st century by moving from incremental to disruptive innovation.

Judge Glock
EP. 032

Judge Glock is the Director of Research and Policy at the Cicero Institute and an expert on housing and homelessness in the U.S.  In this episode, Glock dissects the root causes of America's affordable housing shortage and explains how the right incentives can jumpstart development and bring down home costs for working-class families.  He also exposes how policies like “Housing First” encourage the homeless to live and die on the streets while waiting for free and permanent housing, which won’t solve the root of their problems: addiction and mental illness. Instead, Glock explains how cities like San Diego combine bridge shelters with treatment and accountability to reduce homelessness -- a recipe that other state leaders can use to save lives and bring healing to hundreds of thousands of people. [Joe is the founder and Chairman of Cicero's 501c3 and 501c4 organizations.]

Mark Esper
EP. 033

Dr. Mark Esper served as the U.S. Secretary of Defense from 2019 to 2020 and Secretary of the Army from 2017 to 2019. He's currently the Distinguished Chair of the Modern War Institute at West Point and sits on the Board of Directors of Epirus [a defense startup co-founded by Joe]. His forthcoming memoir is titled "A Sacred Oath: Memoirs of a Secretary of Defense During Extraordinary Times.” In this episode, he dissects Russia's military weaknesses and explains how its invasion of Ukraine may ultimately strengthen NATO and change China's calculations with regard to Taiwan. He and Joe also discuss the risk-averse, top-down management culture at the Pentagon and what needs to change to bring new, better technologies to the Department of Defense.

Jacob DeWitte
EP. 034

Jacob DeWitte is the Co-Founder and CEO of Oklo, a nuclear energy startup building small advanced reactors that can reuse spent fuel from conventional reactors. In this episode, DeWitte explains how the regulatory state has stymied new reactor designs for decades, and how he's working to break through and bring game-changing nuclear power technology to market. Shortly after the initial conversation was filmed, the U.S. Nuclear Regulatory Commission (NRC) denied Oklo's application for its new small reactor design -- evidence of the persistent regulatory challenges. Stay tuned to the end of the episode where Jake rejoins the show to explain how Oklo plans to address the NRC's findings and continue the process toward final approval. [Joe's venture capital firm 8VC is an investor in Oklo.]

Francisco Gimenez
EP. 035

Francisco Gimenez is Partner at 8VC and focuses on Bio-IT investments. He received his Ph.D. from Stanford in Biomedical Informatics and B.S. in Electrical Engineering and Computer Sciences from UC Berkeley. In this episode, Francisco explains how breakthroughs in AI, gene editing, and cell therapies converged to jumpstart a new age in biology. He predicts that biomanufacturing platforms, armed with mountains of data and new tools, will bring down the costs of creating and commercializing drugs so smaller companies can treat rarer diseases and deliver more personalized cures. By decentralizing the pharma industry, Francisco is optimistic that the future of medicine will evolve from reactive care to preventative medicine that will help people fully self-actualize and lead their best, healthiest lives. [Joe is a founding partner of 8VC, his venture capital firm.]

Gene Berdichevsky
EP. 036

Gene Berdichevsky is the co-founder and CEO of Sila, a next-gen battery technology company. Previously, he was the seventh employee at Tesla, where he served as Principal Engineer on the Roadster battery and led the development of the world’s first mass-produced lithium-ion car battery. In this episode, he explains how Sila's new battery chemistry innovations can improve efficiency, reduce costs, and help electrify the future.  He discusses the challenges in mining rare metals, battery recycling, and what's needed to sustainably build batteries at scale. By mid-century, Berdichevsky is optimistic that EVs will become ubiquitous, and we'll be able to fully integrate renewables into the electric grid. [Joe's venture capital firm 8VC is an investor in Sila.]

Zach Latta
EP. 037

Zach Latta is the Founder of Hack Club, a non-profit network of high school coding clubs with over 15,000 members worldwide.  At age 15, Zach helped design one of the most popular apps in the world.  At 16, he dropped out of high school to become a programmer before founding Hack Club.  He then received a Thiel Fellowship and decided to forgo college to build Hack Club full-time.  In this episode, he talks about rethinking education and challenges teenagers to look beyond conventional, safe paths and take full advantage of the Internet Age. He paints an inspiring picture of what our world would look like with more coders and builders -- and explains how Hack Club provides teens with the skills to improve society and realize their full potential. [Joe is a proud early supporter of Hack Club.]

EP. 038

Tony Fadell is one of the great engineers, designers, and business leaders of our time, responsible for creating the iPod, iPhone, and Nest Thermostat.  He runs the investment firm Future Shape and recently released his memoir titled “Build: An Unorthodox Guide to Making Things Worth Making."  In this episode, he discusses the lessons he learned at General Magic (which was building the iPhone 15 years too early) and Philips Electronics that paved the way for building some of the world's most popular devices at Apple. He explains why self-imposed constraints are essential to creating exceptional products and reveals where engineers and designers often go wrong. His passion for building is inspiring and informative for both business and everyday life.

Sebastian Caliri
EP. 039

Sebastian Caliri is Partner at 8VC with a focus on healthcare investing. Previously, Sebastian spent four years at Palantir where he was responsible for growing its commercial healthcare business.  In this episode, Sebastian diagnoses the core problems in U.S. healthcare and explains why traditional fee-for-service care misaligns incentives, resulting in rising costs and inferior health outcomes.  He makes the case for new models like value-based care and also highlights the potential of psychedelic medicine and other exciting innovation. Sebastian holds a BS and MS in Molecular Biophysics & Biochemistry from Yale University and spent a year in Stanford's MD program before pursuing a career in tech and investing.  He argues that the conventional path in medicine is broken and often produces a risk-averse, complacent culture; he challenges the next generation of doctors and health care professionals to think boldly and take on the status quo.

Season 1


EP. 001

Curing cancer, eliminating diseases, reprogramming cells to help 80-year-olds feel like they're 30 -- could it all be possible in our generation? America is in the midst of a biotech revolution that is transforming modern medicine and will save countless lives. At the forefront is Dr. Rick Klausner, former director of U.S. National Cancer Institute, co-founder of Juno Therapeutics, GRAIL, and MindStrong Health, renowned scientist, and billionaire innovator. [Joe has invested with Dr. Klausner in multiple companies, most recently in Dr. Klausner's latest venture, Altos Labs.]

EP. 007

How do you transform a startup into a household name? Ask Sujay Jaswa. When he joined Dropbox in 2010, the company had 16 million users. By the time he left in 2015, hundreds of millions of people relied on Dropbox for their daily web storage needs. As head of the business side of Dropbox and later CFO, Jaswa had a leading role in this transformation, building the business team from scratch and raising over a billion dollars. Today, he serves as Founder and Managing Partner at the investment firm WndrCo and lectures on entrepreneurship at Stanford's Graduate School of Business.

EP. 008

From 2006 to 2015, the Right Honorable Stephen Harper served as the 22nd Prime Minister of Canada. His premiership confronted challenges ranging from a global recession to the war against ISIS, but his smart and courageous leadership increased Canadian prosperity and bolstered security. Small businesses surged, while tech hubs from Waterloo to Toronto to Ottawa cemented their place as global centers of talent and investment. In this episode, Harper offers lessons from his tenure as Prime Minister, from how global leaders should address the aftermath of the coronavirus pandemic to the challenges of a new multipolar world. [PM Harper has been a Senior Advisor to Joe's venture capital firm 8VC for several years.]

EP. 010

Balaji Srinivasan is a bold and forward-thinking writer, investor, and entrepreneur, who was formerly the Chief Technology Officer of Coinbase and general partner at Andreessen Horowitz.  Currently, he's launching innovative ventures, such as his 1729 Project, while also advocating for cryptocurrency and the larger decentralized finance movement. In this episode, he explains how to understand the world by looking through the lenses of three competing factions: the Chinese Communist Party, the "woke" mob, and cryptocurrency maximalists. He also discusses topics ranging from decentralized social media and startup cities to network states and what makes him optimistic on aspects of American innovation.

EP. 011

Niall Ferguson is a renowned historian, Senior Fellow at the Hoover Institution, and prolific author of more than a dozen best-selling works on economics, culture, and politics. In this episode, Ferguson explains why the rise and fall of civilizations do not fit into predictable patterns and cycles.  He does not see American decline as inevitable and holds out that America’s best days may yet be ahead -- if it can stay on the right path.  Ferguson also pulls back the curtain on the Chinese Communist Party, revealing the ways in which the CCP's strengths are exaggerated and why the United States’ support for smart policy and innovation will bolster its dominance in the years ahead.

EP. 013

This week's episode features three talented and successful innovators behind many game-changing technologies and companies. First is Sal Churi, a former law professor who is now general partner at Trust Ventures -- an Austin-based venture capital firm. Next is Keri Findley, a top innovator in the finance industry who was the first female partner at Third Point, a prominent New York-based hedge fund. Finally, Wesley Chan is an engineer turned venture capitalist who was an early employee at Google, and he shares some fascinating insights from those early days.

EP. 014

Jake Kloberdanz is the CEO and Founder of ONEHOPE Wine, an award-winning vineyard located in the heart of Napa Valley. What sets ONEHOPE apart is its unique business model: every bottle of wine sold helps fund a charitable organization. Kloberdanz is a champion of cause-centric commerce, and to date, ONEHOPE has donated over seven million dollars to organizations that help disadvantaged communities break the cycle of poverty. In this episode, he describes his journey from selling wine out of the back of his car to building a world-class winery that also uplifts its community and advances the role of business in society. [Joe is the Chairman of the Board of ONEHOPE.]

EP. 015

In 1978, John Mackey co-founded his first natural foods store in Austin, Texas with only $45,000. Two years later, he and his business partners launched the first Whole Foods Market, which quickly became the nation's fastest-growing organic grocery store. In 2017, Amazon acquired the company for over $13 billion. In this episode, the Whole Foods Founder and CEO discusses his journey from democratic socialism to "Conscious Capitalism" -- the title of his book in defense of free markets and how business, conducted properly, can elevate humanity. He also explains the cultural divide in America today as a clash of three worldviews - traditional, modern, and progressive - and describes how we can pull the best wisdom from each to bridge division and continue to move our society forward.

ep. 016

Maureen Hillenmeyer is the Founder and CEO of Hexagon Bio, a cutting-edge biotech company whose mission is to harvest new drugs and cures from the natural world, beginning with fungi.  In 1928, Sir Alexander Fleming’s accidental discovery of penicillin launched a new age of antibiotics derived from fungi.  However, the process of discovery was slow and laborious.  In this episode, Hillenmeyer explains how Hexagon is using genomic sequencing and artificial intelligence to analyze the millions of types of fungi on earth and uncover new drugs and cures for a host of diseases.  She also issues an important warning about the looming crisis of antibiotic resistance and how Hexagon's work could avert a medical disaster. [Joe's venture capital firm is an investor in Hexagon Bio.]